منابع مشابه
The Mos pathway regulates cytoplasmic polyadenylation in Xenopus oocytes.
Cytoplasmic polyadenylation controls the translation of several maternal mRNAs during Xenopus oocyte maturation and requires two sequences in the 3' untranslated region (UTR), the U-rich cytoplasmic polyadenylation element (CPE), and the hexanucleotide AAUAAA. c-mos mRNA is polyadenylated and translated soon after the induction of maturation, and this protein kinase is necessary for a kinase ca...
متن کاملLocalized XId3 mRNA activation in Xenopus embryos by cytoplasmic polyadenylation
In Xenopus development, during meiosis and cleavage, the extent of polyadenylation plays a central role in regulating the expression of transcripts and this is mediated by cis regulatory cytoplasmic polyadenylation elements (CPE) in the 3'-UTRs. We have identified a palindromic CPE in the mRNA of Xenopus Id3 which is conserved in the Id genes from other vertebrates. It promotes cytoplasmic poly...
متن کاملThe cleavage and polyadenylation specificity factor in Xenopus laevis oocytes is a cytoplasmic factor involved in regulated polyadenylation.
During early development, specific mRNAs receive poly(A) in the cytoplasm. This cytoplasmic polyadenylation reaction correlates with, and in some cases causes, translational stimulation. Previously, it was suggested that a factor similar to the multisubunit nuclear cleavage and polyadenylation specificity factor (CPSF) played a role in cytoplasmic polyadenylation. A cDNA encoding a cytoplasmic ...
متن کاملFurther analysis of cytoplasmic polyadenylation in Xenopus embryos and identification of embryonic cytoplasmic polyadenylation element-binding proteins.
Early development in Xenopus laevis is programmed in part by maternally inherited mRNAs that are synthesized and stored in the growing oocyte. During oocyte maturation, several of these messages are translationally activated by poly(A) elongation, which in turn is regulated by two cis elements in the 3' untranslated region, the hexanucleotide AAUAAA and a cytoplasmic polyadenylation element (CP...
متن کاملCIRP2, a major cytoplasmic RNA-binding protein in Xenopus oocytes.
In an attempt to isolate mRNA-binding proteins we fractionated Xenopus oocyte lysate by oligo(dT)-cellulose chromatography. A 20 kDa protein was the major component of the eluate. cDNA cloning revealed that this protein is a Xenopus homolog of the cold-inducible RNA-binding protein (CIRP) which was originally identified in mammalian cells as a protein that is overexpressed upon a temperature do...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
سال: 2008
ISSN: 1874-9399
DOI: 10.1016/j.bbagrm.2008.02.002